1. Cell Culture Approach to the Study of Granulosa Cells In 1672, Regnier de Graaf first
described the differentiation of ovarian follicles into the corpus luteum. He stated that “age …

Harris (1) first proposed that the anterior pituitary gland is controlled by hypothalamic
releasing factors. After the subsequent purification and sequencing of gonadotropin …

This chapter discusses the modulatory influences regulating the timing of puberty in rats.
The developmental process that leads to puberty in the female rat is based on an …

A form of polycystic ovary (PCO) resembling some aspects of the human PCO syndrome can
be induced in rats by a single injection of estradiol valerate (EV). An increase in sympathetic …

Although FSH receptors are linked to the cAMP second messenger system, additional
intracellular signaling pathways appear to be required for the induction of aromatase and …

The initiation of follicular growth in the mammalian ovary is a gonadotropin-independent
phenomenon. Although some of the intraovarian signaling molecules that control the later …

The ovary is innervated by noradrenergic and peptidergic fibers. Treatment of neonatal rats
with antibodies to nerve growth factor (NGF Ab) resulted in failure of the sympathetic …

The hormonal regulation of inhibin production by cultured granulosa cells from immature
hypophysectomized, estrogen-treated rats was examined using a specific RIA which detects …

In the rat, the main source of adrenergic fibers innervating nonvascular ovarian tissue is the
superior ovarian nerve (SON). To determine the influence of the SON on prepubertal ovarian …

Recent studies have documented the ability of somatomedin-C (Sm-C) to synergize with
FSH in the induction of rat granulosa cell progesterone biosynthesis. This direct …