Benchmark and integration of resources for the estimation of human transcription factor activities
The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
[HTML][HTML] Recent advances in predicting gene–disease associations
K Opap, N Mulder - F1000Research, 2017 - ncbi.nlm.nih.gov
Deciphering gene–disease association is a crucial step in designing therapeutic strategies
against diseases. There are experimental methods for identifying gene–disease …
against diseases. There are experimental methods for identifying gene–disease …
Babelomics 5.0: functional interpretation for new generations of genomic data
Babelomics has been running for more than one decade offering a user-friendly interface for
the functional analysis of gene expression and genomic data. Here we present its fifth …
the functional analysis of gene expression and genomic data. Here we present its fifth …
CSVS, a crowdsourcing database of the Spanish population genetic variability
M Peña-Chilet, G Roldán, J Perez-Florido… - Nucleic acids …, 2021 - academic.oup.com
The knowledge of the genetic variability of the local population is of utmost importance in
personalized medicine and has been revealed as a critical factor for the discovery of new …
personalized medicine and has been revealed as a critical factor for the discovery of new …
Mitochondrial genome architecture in non‐alcoholic fatty liver disease
S Sookoian, D Flichman, R Scian, C Rohr… - The Journal of …, 2016 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction, a
decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To …
decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To …
Epigenetic modifications in the biology of nonalcoholic fatty liver disease: the role of DNA hydroxymethylation and TET proteins
Abstract The 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification whose role in
the pathogenesis of metabolic-related complex diseases remains unexplored; 5-hmC …
the pathogenesis of metabolic-related complex diseases remains unexplored; 5-hmC …
Big linked cancer data: Integrating linked tcga and pubmed
The amount of bio-medical data available on the Web grows exponentially with time. The
resulting large volume of data makes manual exploration very tedious. Moreover, the …
resulting large volume of data makes manual exploration very tedious. Moreover, the …
A web-based interactive framework to assist in the prioritization of disease candidate genes in whole-exome sequencing studies
Whole-exome sequencing has become a fundamental tool for the discovery of disease-
related genes of familial diseases and the identification of somatic driver variants in cancer …
related genes of familial diseases and the identification of somatic driver variants in cancer …