Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …

Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Peroxynitrite (ONOO−) plays a critical role in Alzheimer's disease (AD). To reveal the
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …

The field of nanotechnology has grown over the last two decades and made the transition
from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles …

Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few
treatment options. Here, building on the observation of elevated lactate (LA) in resected …

The major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor
sites accurately and properly activate complex immune responses. Herein, we design and …

Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …