Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …

Copper is an essential trace element for eukaryotes and most prokaryotes. However,
intracellular free copper must be strictly limited because of its toxic side effects. Complex …

Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …

Metal ions, especially with high chemical activity (eg redox-active Cu and Fe) must be
carefully managed in biological systems. The “uncontrolled” activity, eg catalysis of Fenton …

The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the
oxidative phosphorylation complex machinery most notably on the crista membranes …

MIA40 has a key role in oxidative protein folding in the mitochondrial intermembrane space.
We present the solution structure of human MIA40 and its mechanism as a catalyst of …

Redox control in the mitochondrion is essential for the proper functioning of this organelle.
Disruption of mitochondrial redox processes contributes to a host of human disorders …

Copper plays an indispensable role in the physiology of the human central nervous system
(CNS). As a cofactor of dopamine-β-hydroxylase, peptidyl-α-monooxygenase, superoxide …