Caffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic
acid with natural antioxidant and cardio-protective properties. The present study aimed to …

It is now generally accepted that the intracellular ionized magnesium concentration ([Mg2+]
i) in muscle cells is around 1 mmol l-1; in heart muscle this means that from the total some …

Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

Aims Growing evidence suggests that arginase misregulation plays a key role in the
pathophysiology of essential hypertension. In the present study, we investigated the …

Polyamines (putrescine, spermidine and spermine) are essential for cell growth and
differentiation. Nitric oxide exhibits antihypertrophic functions and inhibits cardiac …

Abstract Background Cyclosporine A (CsA)-induced cardiac interstitial fibrosis and cardiac
hypertrophy are highly known phenomena; however, the basic mechanisms of CsA …

Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B).
We determined whether UT-A proteins could be detected in heart and whether their …

The present study was designed to provide a better understanding of the role played by
AdoMetDC (S-adenosylmethionine decarboxylase), the key rate-controlling enzyme in the …

Background: Polyamines and nitric oxide (NO) have been involved in the pathogenesis of
cardiac hypertrophy. NO can regulate cardiac ion channels by direct actions on G-proteins …

It is well established that the intracellular receptors of androgens act as transcription factors
upon their activation by androgen binding. However, a growing number of studies have …