Several mutant genetic classes that cause isolated methylmalonic acidurias (MMAuria) are
known based on biochemical, enzymatic and genetic complementation analysis. The mut0 …

Cobalamin deficiency in the newborn usually results from cobalamin deficiency in the
mother. Megaloblastic anaemia, pancytopenia and failure to thrive can be present …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Methylmalonic aciduria and homocystinuria, cblC type (OMIM 277400), is the most common
inborn error of vitamin B12 (cobalamin) metabolism, with about 250 known cases. Affected …

Derivatives of cobalamin (vitamin B12) are required for activity of two enzymes in humans.
Adenosylcobalamin is required for activity of mitochondrial methylmalonylCoA mutase and …

Vitamin B12 (cobalamin) is essential in animals for metabolism of branched chain amino
acids and odd chain fatty acids, and for remethylation of homocysteine to methionine. In the …

Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways.
Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in …

Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …

Vitamin B12 (cobalamin) is an essential cofactor of two enzymes, methionine synthase and
methylmalonyl-CoA mutase. The conversion of the vitamin to its coenzymes requires a …

Many coenzymes are vitamins that are assimilated in mammals into their active form from
precursors obtained from the diet. They are often both rare and reactive rendering the …