Sound strategies for hearing restoration
GSG Géléoc, JR Holt - Science, 2014 - science.org
Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …
Emerging gene therapies for genetic hearing loss
H Ahmed, O Shubina-Oleinik, JR Holt - … of the Association for Research in …, 2017 - Springer
Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
LD Landegger, B Pan, C Askew, SJ Wassmer… - Nature …, 2017 - nature.com
Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe,
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …
Tmc gene therapy restores auditory function in deaf mice
C Askew, C Rochat, B Pan, Y Asai, H Ahmed… - Science translational …, 2015 - science.org
Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are
no biologic treatments currently available. To investigate gene therapy as a potential …
no biologic treatments currently available. To investigate gene therapy as a potential …
[HTML][HTML] Meniere's disease might be an autoimmune condition?
OBJECTIVES: To review our current knowledge of the pathogenesis of Meniere's disease,
including viral infection and immune system-mediated mechanisms, and to discuss the …
including viral infection and immune system-mediated mechanisms, and to discuss the …
Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
L Lossi, S Alasia, C Salio, A Merighi - Progress in neurobiology, 2009 - Elsevier
Analysis of the interplay between cell proliferation and death has been greatly advantaged
by the development of CNS slice preparations. In slices, interactions between neurons and …
by the development of CNS slice preparations. In slices, interactions between neurons and …
Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear
LA Kilpatrick, Q Li, J Yang, JC Goddard, DM Fekete… - Gene therapy, 2011 - nature.com
Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …
mutations have been discovered and mapped within the mouse genome. However, because …
[HTML][HTML] Recent advancements in the regeneration of auditory hair cells and hearing restoration
R Mittal, D Nguyen, AP Patel, LH Debs… - Frontiers in molecular …, 2017 - frontiersin.org
Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …
[HTML][HTML] Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss
There is growing attention and effort focused on treating the root cause of sensorineural
hearing loss rather than managing associated secondary characteristic features. With recent …
hearing loss rather than managing associated secondary characteristic features. With recent …
[HTML][HTML] Regenerating hair cells in vestibular sensory epithelia from humans
Human vestibular sensory epithelia in explant culture were incubated in gentamicin to
ablate hair cells. Subsequent transduction of supporting cells with ATOH1 using an Ad-2 …
ablate hair cells. Subsequent transduction of supporting cells with ATOH1 using an Ad-2 …