[HTML][HTML] Immunotherapy of glioblastoma: current strategies and challenges in tumor model development
Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …
immunotherapy is playing an increasingly central role in the treatment of many cancers …
[HTML][HTML] Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …
role in several processes—such as protein degradation, changes in cell signaling, cell …
Inability of ovarian cancers to upregulate their MHC-class I surface expression marks their aggressiveness and increased susceptibility to NK cell-mediated cytotoxicity
We extended our previous observations with other tumor models to study seven ovarian
tumor cell lines—OVCAR3, OVCAR4, OVCAR8, SKOV3, Kuramochi, OAW28, and CaOV3 …
tumor cell lines—OVCAR3, OVCAR4, OVCAR8, SKOV3, Kuramochi, OAW28, and CaOV3 …
Natural killer cells in the treatment of glioblastoma: Diverse antitumor functions and potential clinical applications
B Breznik, M Novak, B Majc, A Habič… - NK Cells in Cancer …, 2023 - Elsevier
Natural killer (NK) cells are cytotoxic lymphocytes of innate immunity that recognize and kill
stressed, infected, and cancer cells. Moreover, NK cells orchestrate innate and adaptive …
stressed, infected, and cancer cells. Moreover, NK cells orchestrate innate and adaptive …
[HTML][HTML] an update on glioblastoma biology, genetics, and current therapies: Novel inhibitors of the g protein-coupled receptor CCR5
T Lah Turnšek, X Jiao, M Novak, S Jammula… - International journal of …, 2021 - mdpi.com
The mechanisms governing therapeutic resistance of the most aggressive and lethal primary
brain tumor in adults, glioblastoma, have increasingly focused on tumor stem cells. These …
brain tumor in adults, glioblastoma, have increasingly focused on tumor stem cells. These …
[HTML][HTML] The potential role of cytotoxic immune effectors in induction, progression and pathogenesis of amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is an auto-immune neurodegenerative disorder affecting
the motor-neuron system. The causes of ALS are heterogeneous, and are only partially …
the motor-neuron system. The causes of ALS are heterogeneous, and are only partially …
[HTML][HTML] Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
[HTML][HTML] Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas
High-grade serous ovarian cancers (HGSOCs) likely consist of poorly differentiated stem-
like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable …
like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable …
Multifaceted nature of natural killer cells: Potential mode of interaction and shaping of stem cells
Natural killer (NK) cells are the key immune effectors with the ability to lyse stem-like/poorly
differentiated tumor cells and mediate differentiation through their cytotoxic activity and via …
differentiated tumor cells and mediate differentiation through their cytotoxic activity and via …
[HTML][HTML] Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and
induces cell death of oral and pancreatic tumor cells, and the effect is much more …
induces cell death of oral and pancreatic tumor cells, and the effect is much more …