Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

Z Xu, X Han, D Ou, T Liu, Z Li, G Jiang, J Liu… - Applied microbiology …, 2020 - Springer
Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Bufalin for an innovative therapeutic approach against cancer

L Soumoy, GE Ghanem, S Saussez, F Journe - Pharmacological Research, 2022 - Elsevier
Bufalin is an endogenous cardiotonic steroid, first discovered in toad venom but also found
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

C Cheng, J Wang, J Chen, KT Kuo, J Tang… - Cancer Cell …, 2019 - Springer
Aim of the review In the past decade, increasing research attention investigated the novel
therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its …

Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy

Y Xu, Y Liu, Q Liu, S Lu, X Chen, W Xu, F Shi - Journal of Controlled …, 2021 - Elsevier
Albumin nanoparticles represent an approved anti-tumor drug delivery system. However,
there is only one albumin nanoparticle product (paclitaxel-albumin nanoparticle) on the …

RETRACTED ARTICLE: The circular RNA hsa-circ-0072309 plays anti-tumour roles by sponging miR-100 through the deactivation of PI3K/AKT and mTOR pathways …

T Chen, S Shao, W Li, Y Liu, Y Cao - Artificial Cells, Nanomedicine …, 2019 - Taylor & Francis
We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and
Biotechnology, have retracted the following article: Tao Chen, Shixiu Shao, Wenxian Li …

Bufalin-mediated regulation of cell signaling pathways in different cancers: spotlight on JAK/STAT, Wnt/β-catenin, mTOR, TRAIL/TRAIL-R, and non-coding RNAs

AA Farooqi, VS Rakhmetova, G Kapanova… - Molecules, 2023 - mdpi.com
The renaissance of research into natural products has unequivocally and paradigmatically
shifted our knowledge about the significant role of natural products in cancer …

Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment

LJ Deng, Y Li, M Qi, JS Liu, S Wang, LJ Hu… - European journal of …, 2020 - Elsevier
Bufadienolides are cardioactive C24 steroids with an α-pyrone ring at position C17. In the
last ten years, accumulating studies have revealed the anticancer activities of …

Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF‐α pathway

S Su, H Dou, Z Wang, Q Zhang - Basic & Clinical …, 2021 - Wiley Online Library
Ovarian cancer is a severe health threat for women with increased incidence and stymied
development in diagnosis and therapy. Drug resistance is still a big challenge. Bufalin is a …

Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma

Y Hao, C Zhang, Y Sun, H Xu - OncoTargets and therapy, 2019 - Taylor & Francis
Background Oral squamous cell carcinoma (OSCC) is one of the most common cancers,
with high metastasis and mortality. Licochalcone A (LCA) is a chalconoid from the root of …

Molecular mechanisms and physiological functions of autophagy in kidney diseases

J Yang, L Yuan, F Liu, L Li, J Liu, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic
contents including micromolecules, misfolded proteins, and damaged organelles that has …