The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …

The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …

Hematotoxicity represents a frequent chimeric antigen receptor (CAR) T-cell–related
adverse event and remains poorly understood. In this multicenter analysis, we studied …

Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic
stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an
acquired genetic variant, emerges with age. Although in general CH is associated with …

Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …

Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs)
drive clonal hematopoiesis (CH). While some CH drivers have been identified, the …

Contribution: CM, L.-PZ, RDdO, MC, NG, and BR collected the data; CM and L.-PZ analyzed
the data and wrote the manuscript; EV, NM, EC, and BC performed molecular analyses; JS …

NPM 1-mutated acute myeloid leukemia (AML) shows unique features. However, the
characteristics of “therapy-related” NPM1-mutated AML (t-NPM1 AML) are poorly …