Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …

Histone variants provide versatility in the basic unit of chromatin, helping to define dynamic
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …

Tyrosine sulfation is a common posttranslational modification in mammals. To date, it has
been thought to be limited to secreted and transmembrane proteins, but little is known about …

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for
faithful chromosome segregation and genome integrity maintenance through cell divisions …

Histone chaperones are key regulators of chromatin structure and function. Their frequent
mis-regulation in various cancers can impact tumor initiation and progression. Here, we …

Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …

The lack of a consensus DNA sequence defining replication origins in mammals has led
researchers to consider chromatin as a means to specify these regions. However, to date …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Adult stem cells undergo asymmetric cell divisions to produce 2 daughter cells with distinct
cell fates: one capable of self-renewal and the other committed for differentiation …

We propose that several chromatin-mediated regulatory processes are dominated by source-
sink relationships in which factors operate as 'sources' to produce or provide a resource and …