Derivatives of quinazolines constitute a large group of chemicals with a wide range of
biological properties. The character of quinazolines depends mostly on the properties of the …

Quinazolines are among the most useful heterocyclic compounds due to their diverse
chemical reactivity and a wide range of biological activity. Despite a large number of …

Background Although lung adenocarcinoma (LADC) with sensitizing mutations of the
epidermal growth factor receptor (EGFR) is highly sensitive to EGFR tyrosine kinase …

Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification
of the protein. The human genome encodes approximately 538 kinases. Kinases play a role …

Background. Prior research has identified ANGPTL4 as a key player in the control of the
body's lipid and glucose metabolism and a contributor to the onset of numerous …

Tyrosine kinase inhibitors are taking up an increasingly significant role in treating cancers.
There are different types of TKIs currently used in clinical settings. However, TKI-associated …

Kanker paru merupakan tumor ganas di paru-paru yang asalnya dari epitel saluran nafas.
Faktor penyebab kanker paru adalah mutasi gen pada jalur sinyal Epidermal Growth Factor …

Macrophages are a major component of the leukocyte infiltrate of tumor microenvironment.
Their involvement in tumor progression was demonstrated for many cancers, including …

Adanya identifikasi Epidermal Growth Factor Receptor (EGFR) sebagai target molekular
mempengaruhi model terapi kanker paru jenis Non-Small Cell Lung Cancer (NSCLC) …

In recent decades, with the accessibility and application of different anti-tumor treatments,
the survival of cancer patients has improved. Nevertheless, the overall survival rate in …