Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease,
cerebrovascular disease, and peripheral arterial disease, represent a significant cause of …

Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma
concentration of 1.5–3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The …

Fibrinogen is an extraordinary molecule by any estimation. It is large, structurally intricate,
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …

Biomolecular corona formation has emerged as a recurring and important phenomenon in
nanomedicine that has been investigated for potential applications in disease diagnosis. In …

A nonenzymatic reaction between reducing sugars and amino groups of proteins results in
the formation of advanced glycation end products, which are linked to a number of chronic …

Despite improved diagnosis and treatment options, coronary artery disease (CAD) is still the
leading cause of mortality and morbidity worldwide. Established risk factors such as …

BACKGROUND: Acute ischemic stroke (AIS) is associated with enhanced oxidative stress
and unfavorably altered fibrin clot properties. We investigated determinants of plasma …

Chronic kidney disease leads to the accumulation of uremic toxins within the blood
compartment. Engineered surface that adsorbs toxins from the blood compartment is a …

Patients with cirrhosis frequently acquire profound hemostatic alterations, which may affect
thrombus quality and composition—factors that determine the susceptibility to embolization …