Simultaneous determination of gefitinib and its major metabolites in mouse plasma by HPLC–MS/MS and its application to a pharmacokinetics study

N Zheng, C Zhao, XR He, ST Jiang, SY Han… - … of Chromatography B, 2016 - Elsevier
Gefitinib (Iressa) is the first oral EGFR tyrosine kinase inhibitor and it brings benefits to non-
small cell lung cancer patients with EGFR mutation. In this study, a simple, rapid and …

[HTML][HTML] Establishment of a pre-vascularized 3D lung cancer model in fibrin gel—influence of hypoxia and cancer-specific therapeutics

C Kniebs, AE Luengen, D Guenther… - … in bioengineering and …, 2021 - frontiersin.org
Lung cancer is the most frequently diagnosed cancer worldwide and the one that causes the
highest mortality. In order to understand the disease and to develop new treatments, in vitro …

Development and validation of a sensitive LC–MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in non-small …

S Guan, X Chen, F Wang, S Xin, W Feng, X Zhu… - … of pharmaceutical and …, 2019 - Elsevier
Gefitinib, the first approved oral epidermal growth factor receptor (EGFR) inhibitor, has been
demonstrated effective in cancers with EGFR active mutations. In this study, we established …

Inhibition of EZH2 and EGFR produces a synergistic effect on cell apoptosis by increasing autophagy in gastric cancer cells

Y Yang, F Zhu, Q Wang, Y Ding, R Ying… - OncoTargets and …, 2018 - Taylor & Francis
Background Numerous reports have shown that a combination of two or more drugs leads to
better cancer treatment. Inhibitors of zeste homology 2 and epidermal growth factor receptor …

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP …

T Zhao, X Li, Y Chen, J Du, X Chen, D Wang… - Frontiers in …, 2022 - frontiersin.org
Cancer patients generally has a high risk of thrombotic diseases. However, anticoagulant
therapy always aggravates bleeding risks. Rivaroxaban is one of the most widely used direct …

Cordyceps acid alleviates lung cancer in nude mice

J Wang, H Chen, W Li, L Shan - Journal of Biochemical and …, 2021 - Wiley Online Library
The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice.
A lung cancer animal model was established by inoculating lung cancer cells under the …

[HTML][HTML] The association between clinical prognostic factors and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced non-small …

JH Lin, D Lin, L Xu, Q Wang, HH Hu, HP Xu, ZY He - Oncotarget, 2017 - ncbi.nlm.nih.gov
Objective This study aimed to examine the association of clinical prognostic factors with
epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced …

Characterizing cancer drug response and biological correlates: a geometric network approach

M Pouryahya, JH Oh, JC Mathews, JO Deasy… - Scientific reports, 2018 - nature.com
In the present work, we apply a geometric network approach to study common biological
features of anticancer drug response. We use for this purpose the panel of 60 human cell …

Nanoparticle-mediated metronomic chemotherapy in cancer: A paradigm of precision and persistence

A Kirti, FZ Simnani, S Jena, SS Lenka, C Kalalpitiya… - Cancer Letters, 2024 - Elsevier
Current methods of cancer therapy have demonstrated enormous potential in tumor
inhibition. However, a high dosage regimen of chemotherapy results in various …

Serum exosomal m6A demethylase FTO promotes gefitinib resistance in non-small cell lung cancer by up-regulating FLRT3, PTGIS and SIRPα expression

Q Wang, L Zhang, Z Su, W Li, Y Jia, J Zhang - Pulmonary Pharmacology & …, 2023 - Elsevier
This study investigates the molecular mechanism of FTO m6A demethylase in non-small cell
lung cancer (NSCLC) and gefitinib resistance using GEO and TCGA databases …