Protein S-acylation or palmitoylation is a widespread post-translational modification that
consists of the addition of a lipid molecule to cysteine residues of proteins through a …

Receptor tyrosine kinases (RTKs) are membrane receptors that regulate many fundamental
cellular processes. A tight regulation of RTK signaling is fundamental for development and …

Lung cancer ranks as the second most commonly diagnosed cancer in both men and
women worldwide. Despite the availability of diverse diagnostic and treatment strategies, it …

Renal cell carcinoma (RCC) is the most common renal malignancy with a rapidly increasing
morbidity and mortality rate gradually. RCC has a high mortality rate and an extremely poor …

The effects of intravenous gefitinib (10 mg/kg), an anilinoquinazoline thymidylate kinase
inhibitor (TKI), selective for the epidermal growth factor receptor (EGFR), on the urinary …

The metabolism and pharmacokinetics of gefitinib (Iressa®, N-(3-chloro-4-fluorophenyl)-7-
methoxy-6-(3-morpholino-propoxy) quinazolin-4-amine), a selective thymidylate kinase …

The modular synthesis of the guanidine core by guanylation reactions using commercially
available ZnEt2 as a catalyst has been exploited as a tool for the rapid development of …

Advanced therapy-refractory solid tumors bear a dismal prognosis and constitute a major
challenge in offering effective treatment strategies. In this real-world retrospective analysis of …

Amino acid derived polypeptides are often biocompatible, and hence the materials of choice
in nanoparticle formulations to avoid nanotoxicity and associated complications. A …

Significance analysis of proteomic data generated by LC‐MS/MS is challenging owing to
great data variability originated from biological, operational, and instrumental variations …