Background. Salmonella species are motile, Gram-negative facultative anaerobic bacilli,
which belong to the family Enterobacteriaceae. The most common clinical presentations of …

The present study aimed to investigate the association and underlying mechanisms
between microRNA-200b level and the inhibitory effect of gefitinib on non-small cell lung …

背景与目的表皮生长因子受体(epidermal growth factor receptor, EGFR) 酪氨酸激酶抑制剂(
tyrosine kinase inhibitors, TKIs) 被用于治疗进展性晚期非小细胞肺癌(non-small cell lung …

An efficient solid-phase synthesis approach is here reported for the first time to prepare the
EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid …

目的: 探讨苦参碱对非小细胞肺癌(non-small lung cancer cell, NSCLC) 顺铂耐药性的逆转作用
及其机制. 方法: MTT 法检测细胞存活率; 采用试剂盒检测细胞乳酸脱氢酶及caspase-3 活性 …

Background: Tyrosine kinase inhibitors are widely used in the treatment of non-small cell
lung cancer. However, the exact role of these inhibitors, particularly in the reduction of …

In order to find novel antitumor candidate agents with high efficiency and low toxicity, 14
novel substituted 5‐anilino‐α‐glucofuranose derivatives have been designed, synthesized …

A novel design and efficient protocol for the synthesis of new class of 6-substituted
quinazoline-2-thiols is reported. The derivatization of the thioquinazolines is achieved in a …

Globally widespread cancer causes an urgent need to develop innovative, more potent
drugs that can deliver better therapeutic outcomes. The study aimed to synthesize pyazolo …

Human adenovirus type 5 (HAdV-5)-based oncolytic virotherapy holds promise as efficient
anti-cancer therapy. Beside a direct virus-induced cancer cell lysis, the resultant release of …