Deciphering the lexicon of protein targets: a review on multifaceted drug discovery in the era of artificial intelligence
Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …
protein interactions (PPIs), which are essential for many biological processes and diseases …
[HTML][HTML] Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
M Podolak, S Holota, Y Deyak, K Dziduch… - Bioorganic …, 2023 - Elsevier
Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
[HTML][HTML] Nanotechnological synergy of mangiferin and curcumin in modulating PI3K/Akt/mTOR pathway: a novel front in ovarian cancer precision therapeutics
HM Alharbi, T Alqahtani, AH Alamri… - Frontiers in …, 2024 - frontiersin.org
Background: Ovarian cancer, colloquially termed the “silent killer” among gynecological
malignancies, remains elusive due to its often-asymptomatic progression and diagnostic …
malignancies, remains elusive due to its often-asymptomatic progression and diagnostic …
Small molecule heat shock protein 27 inhibitor J2 decreases ovarian cancer cell proliferation via induction of apoptotic pathways
D Karademir, A Özgür - Medical Oncology, 2023 - Springer
Abstract Heat shock protein 27 (Hsp27) is an important member of the chaperone protein
family and its overexpression promotes cancer cell survival. Here, we investigated the …
family and its overexpression promotes cancer cell survival. Here, we investigated the …
[HTML][HTML] Resistance to gemcitabine in pancreatic cancer is connected to methylglyoxal stress and heat shock response
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis.
Gemcitabine is the first-line therapy for PDAC, but gemcitabine resistance is a major …
Gemcitabine is the first-line therapy for PDAC, but gemcitabine resistance is a major …
[HTML][HTML] Exploring the efficacy of 1-amino-cyclopropane-1-carboxylic acid (ACCA) as a natural compound in strengthening maize resistance against biotic and abiotic …
Objective This study aims to understand plant-bacteria interactions that enhance plant
resistance to environmental stressors, with a focus on maize (Zea mays L.) and its …
resistance to environmental stressors, with a focus on maize (Zea mays L.) and its …
Exploring the potency of curcumin and phyto-compounds as inhibitors of tomato yellow leaf curl virus-sardinia's DNA-binding domain: a computational approach
Background With the current rise of Tomato yellow leaf curl virus-Sardinia (TYLCV-Sar), a
pathogen causing significant yield losses, conventional pesticides have proven inadequate …
pathogen causing significant yield losses, conventional pesticides have proven inadequate …
[HTML][HTML] Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua)
Background Cancer is one of the leading causes of death worldwide. Recently, it was shown
that many natural extracts have positive effects against cancer, compared with …
that many natural extracts have positive effects against cancer, compared with …
[HTML][HTML] Iodine-biofortified lettuce can promote mitochondrial dependent pathway of apoptosis in human gastrointestinal cancer cells
O Sularz, A Koronowicz, S Smoleń, C Boycott… - International Journal of …, 2023 - mdpi.com
Previously, our research provided evidence that exposure of gastric and colon cancer cells
to extracts from iodine-biofortified lettuce leads to a reduction of cell viability and proliferation …
to extracts from iodine-biofortified lettuce leads to a reduction of cell viability and proliferation …
Inhibition of tomato spotted wilt virus nucleocapsid protein using phytochemical lupenone as spraying agent: A cutting-edge computational approach
About & background Tomato spotted wilt virus (TSWV) is one of the most harmful diseases
affecting the growing and making of tomatoes (Solanum lycopersicum) worldwide. With so …
affecting the growing and making of tomatoes (Solanum lycopersicum) worldwide. With so …