Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Aims Whether and how iron affects the progression of atherosclerosis remains highly
debated. Here, we investigate susceptibility to atherosclerosis in a mouse model (ApoE …

IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose
principal function is contraction. The fully differentiated or mature SMC proliferates at an …

Inflammation is involved in pathogenesis of hypertension. NLRP3 inflammasome activation
is a powerful mediator of inflammatory response via caspase-1 activation. The present study …

Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …

Intimal hyperplasia is the process by which the cell population increases within the
innermost layer of the arterial wall, such as occurs physiologically during closure of the …