Green tea polyphenols and their potential role in health and disease
M Afzal, AM Safer, M Menon - Inflammopharmacology, 2015 - Springer
There is a growing body of evidence that plant polyphenols such as resveratrol,
anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of …
anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of …
[HTML][HTML] Suppressive effects of EGCG on cervical cancer
YQ Wang, JL Lu, YR Liang, QS Li - Molecules, 2018 - mdpi.com
Cervical cancer is the fourth most common gynecological cancer worldwide. Although
prophylactic vaccination presents the most effective method for cervical cancer prevention …
prophylactic vaccination presents the most effective method for cervical cancer prevention …
Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer
ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …
overexpression is frequently observed in a wide variety of human cancers, while often being …
[HTML][HTML] Catechins-modified selenium-doped hydroxyapatite nanomaterials for improved osteosarcoma therapy through generation of reactive oxygen species
Osteosarcoma is the most common bone cancer with limited therapeutic options. It can be
treated by selenium-doped hydroxyapatite owing to its known antitumor potential. However …
treated by selenium-doped hydroxyapatite owing to its known antitumor potential. However …
Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73
W Ashraf, T Ahmad, NAR Almalki, M Krifa, L Zaayter… - Food & function, 2022 - pubs.rsc.org
Maritime pine bark is a rich source of polyphenolic compounds and is commonly employed
as a herbal supplement worldwide. This study was designed to check the potential of …
as a herbal supplement worldwide. This study was designed to check the potential of …
[HTML][HTML] Identification of epigallocatechin-3-gallate as an inhibitor of phosphoglycerate mutase 1
X Li, S Tang, QQ Wang, ELH Leung, H Jin… - Frontiers in …, 2017 - frontiersin.org
Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer
therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly …
therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly …
Optimized Plk1 PBD inhibitors based on poloxin induce mitotic arrest and apoptosis in tumor cells
A Scharow, M Raab, K Saxena… - ACS chemical …, 2015 - ACS Publications
Polo-like kinase 1 (Plk1) is a central regulator of mitosis and has been validated as a target
for antitumor therapy. The polo-box domain (PBD) of Plk1 regulates its kinase activity and …
for antitumor therapy. The polo-box domain (PBD) of Plk1 regulates its kinase activity and …
Development of a polo-like kinase-1 polo-box domain inhibitor as a tumor growth suppressor in mice models
P Gunasekaran, MS Yim, M Ahn… - Journal of medicinal …, 2020 - ACS Publications
Polo-like kinase-1 (Plk1) plays a key role in mitosis and has been identified as an attractive
anticancer drug target. Plk1 consists of two drug-targeting sites, namely, N-terminal kinase …
anticancer drug target. Plk1 consists of two drug-targeting sites, namely, N-terminal kinase …
[HTML][HTML] Anti-tumor pharmacology of natural products targeting mitosis
M Huang, C Liu, Y Shao, S Zhou, G Hu… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Cancer has been an insurmountable problem in the history of medical science. The
uncontrollable proliferation of cancer cells is one of cancer's main characteristics, which is …
uncontrollable proliferation of cancer cells is one of cancer's main characteristics, which is …
[HTML][HTML] Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
G Wang, J Wang, MR Momeni - Cancer Cell International, 2023 - Springer
Green tea, a popular and healthy nonalcoholic drink consumed globally, is abundant in
natural polyphenols. One of these polyphenols is epigallocatechin-3-gallate (EGCG), which …
natural polyphenols. One of these polyphenols is epigallocatechin-3-gallate (EGCG), which …