The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Starting at birth, the intestinal microbiota changes dramatically from a highly individual
collection of microorganisms, dominated by comparably few species, to a mature …

Background: Patients with primary antibody deficiencies are at risk in the current COVID-19
pandemic due to their impaired response to infection and vaccination. Specifically, patients …

Common variable immunodeficiency (CVID) is the most common clinically significant
primary immunodeficiency in adulthood, which presents a broad spectrum of clinical …

Background Common variable immunodeficiency (CVID) is usually well controlled with
immunoglobulin substitution and immunomodulatory drugs. A subgroup of patients has a …

Objective Several lines of evidence indicate that B cells may be involved in the
immunopathology of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). This study …

BACKGROUND: Ataxia telangiectasia (AT) is a multisystem DNA-repair disorder caused by
mutations in the ataxia telangiectasia mutated (ATM) gene. Patients with AT have reduced B …