The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

In eukaryotic cells, mitochondria perform cellular respiration through a series of redox
reactions ultimately reducing molecular oxygen to water. The system responsible for this …

Mounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress
responses can activate the inflammasome, which generally results in endothelial …

Glyphosate, the most widely used herbicide worldwide, has been reported to cause
hepatotoxicity. However, these systematic mechanisms remain poorly understood. Here, we …

During pregnancy, the human body is quite vulnerable to external stimuli. Zinc oxide
nanoparticles (ZnO-NPs) are widely used in daily life, and they enter the human body via …

Abstract Human Tim8a and Tim8b are paralogous intermembrane space proteins of the
small TIM chaperone family. Yeast small TIMs function in the trafficking of proteins to the …

Obesity is on the rise worldwide, and consequently, obesity-related non-communicable
diseases are as well. Nutritional overload induces metabolic adaptations in an attempt to …

Introduction The analysis of the role of the mitochondria in oxidative damage and skin aging
has been a significant aspect of dermatological research. Mitochondria generate most …

The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial
respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic …