Biogenic amines—polyamines (PAs), particularly putrescine, spermidine and spermine are
ubiquitous in all living cells. Their indispensable roles in many biochemical and …

Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …

Polyamines are ubiquitous small basic molecules that play multiple essential roles in
mammalian physiology. Their cellular content is highly regulated and there is convincing …

The polyamines putrescine, spermidine, and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …

Polyamines are ubiquitous and essential components of mammalian cells. They have
multiple functions including critical roles in nucleic acid and protein synthesis, gene …

The polyamines spermidine and spermine and their diamine precursor putrescine are
naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth …

Spermidine/spermine-N 1-acetyltransferase (SSAT) regulates cellular polyamine content. Its
acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase …

Nearly 80% of the approved human therapeutic antibodies are produced by Chinese
Hamster Ovary (CHO) cells. To achieve better cell growth and high-yield recombinant …

In addition to polyamine homoeostasis, it has become increasingly clear that polyamine
catabolism can play a dominant role in drug response, apoptosis and the response to …