Alzheimer's disease
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
Brain lipidomics: From functional landscape to clinical significance
JH Yoon, Y Seo, YS Jo, S Lee, E Cho… - Science …, 2022 - science.org
Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …
[HTML][HTML] The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction
EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease
Background Alzheimer's disease is a debilitating and highly heritable neurological
condition. As such, genetic studies have sought to understand the genetic architecture of …
condition. As such, genetic studies have sought to understand the genetic architecture of …
[HTML][HTML] Microglia in Alzheimer disease: well-known targets and new opportunities
AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …
in brain development, and physiology during life and aging. Equipped with a variety of …
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and
without Alzheimer disease (AD; n control= 13; n AD= 83) from the Knight Alzheimer Disease …
without Alzheimer disease (AD; n control= 13; n AD= 83) from the Knight Alzheimer Disease …
Rodent models for Alzheimer disease
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …
course of more than two decades, an increasing number of complementary rodent models …
[HTML][HTML] Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
AM Arranz, B De Strooper - The Lancet Neurology, 2019 - thelancet.com
Background Astrocytes, also called astroglia, maintain homoeostasis of the brain by
providing trophic and metabolic support to neurons. They recycle neurotransmitters …
providing trophic and metabolic support to neurons. They recycle neurotransmitters …
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …