An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

High plasma levels of homocysteine are the results of the interplay between congenital and
environmental factors. In the last two decades, a growing amount of interest has focused on …

Context.—Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular
disease, but the strength of the relationship and the interaction of plasma homocysteine with …

Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for
cardiovascular disease. This fact has produced a new, increased interest in the study of …

Homocysteine is a sulfur amino acid with a free sulfhydryl group (Fig. 1). It was first
discovered by du Vigneaud in 1932 as a product of demethylation of methionine (1). The …

The clbC form of methylmalonic acidaemia is a rare and poorly understood condition which
results from impaired biosynthesis of methylcobalamin and adenosylcobalamin. The …

Optimal functioning of the central and peripheral nervous system is dependent on a constant
supply of appropriate nutrients. Neurologic signs occur late in malnutrition. Deficiency …

Optimal functioning of the central and peripheral nervous system is dependent on a constant
supply of appropriate nutrients. Estimates provided by the United Nations Food and …

Hyperhomocyst (e) inemia is a metabolic derangement that is linked to the distribution of
folate pools, which provide one-carbon units for biosynthesis of purines and thymidylate and …

Deficient activity of an enzyme can result from a defect in the conversion of the vitamin to a
co-enzyme as well from an abnormal apo-enzyme or disturbed binding of co-enzyme to …