Cancer cell metabolism differs significantly from the metabolism of non-transformed cells.
This altered metabolic reprogramming mediates changes in the uptake and use of nutrients …

Recently, we have shown that ornithine decarboxylase (ODC), a rate-controlling enzyme in
the polyamine biosynthetic pathway, is overexpressed in prostate cancer (PCA) and …

Prostate cancer (PCA), the most commonly diagnosed cancer in males in the United States,
is the second leading cause of cancer-related deaths of males in this country. Because of …

Literature on the effect of steroid hormones (androgens, estrogens, and other steroids), of
peptide hormones (eg, prolactin), and growth factors (eg, EGF, FGF, TGF‐β), on the effect of …

BACKGROUND Spermidine synthase, an essential enzyme in the polyamine synthesis
pathway, was identified as one of the androgen‐response genes in the rat ventral prostate …

I cervelli atti pih alla IoquacitB ed ostentazione, the alla specolazione ed investigazione
dell'opere piti segrete di natura; li quali, prima the ridursi a profferir quella savia ingenua e …

Difluoromethylornithine is a noncompetitive inhibitor of ornithine decarboxylase, which
catalyzes the ratelimiting step in polyamine synthesis. Induction of ornithine decarboxylase …

The dose‐dependent induction of ornithine decarboxylase (ODC) and adenosylmethionine
decarboxylase (AMDC) activity in the different lobes of the prostate and the seminal vesicles …

Endogenous levels of the polyamines putrescine, spermidine, and spermine have been
examined in the 106 m/s2 supernatant of different lobes of the rat prostate and in the …

Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first
and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using …