Bryostatin‐1 is a powerful protein kinase C (PKC) agonist, activating PKC isozymes at
nanomolar concentrations. Pharmacological studies of bryostatin‐1 have mainly been …

Dementia and depression are clinical symptoms commonly associated in patients. Emerging
evidence suggests that the two diseases share many profiles in their development and …

Neuropathic pain concurrent with mood disorder from peripheral nerve injury is a serious
clinical problem that significantly affects quality of life. Recent studies have suggested that a …

The last decade has witnessed a rapid progress in understanding of the molecular cascades
that may underlie memory and memory disorders. Among the critical players, activity of …

Depression is characterized by a lack of “motivation” rather than a lack of “physical space” to
move around. This study was designed to evaluate predictivity of an open space swimming …

While it is generally accepted that cognitive processes such as learning and memory are
affected by emotion, the impact of depression on learning and memory has rarely been …

Depression-like behavior is often complicated by chronic pain. Antidepressants including
imipramine (IMI) are widely used to treat chronic pain, but the mechanisms are not fully …

While laughter has been shown to play a significant role in any social interaction; its
conversational usage by a person with dementia has rarely been investigated. This paper …

The aim of this study was to evaluate the protective effects of p-chloro-diphenyl diselenide (p-
ClPhSe) 2 on depressant-like action and cognitive impairment caused by aging in male rats …

Novel 5-HT1 autoreceptor ligands based on the N-4-aryl-piperazinyl-N′-ethyl-5, 6, 7, 8-
tetrahydropyrido [4′, 3′: 4, 5] thieno [2, 3-d] pyrimidin-4 (3H)-one core are described …