Bryostatin‐1: Pharmacology and Therapeutic Potential as a CNS Drug
MK Sun, DL Alkon - CNS Drug Reviews, 2006 - Wiley Online Library
Bryostatin‐1 is a powerful protein kinase C (PKC) agonist, activating PKC isozymes at
nanomolar concentrations. Pharmacological studies of bryostatin‐1 have mainly been …
nanomolar concentrations. Pharmacological studies of bryostatin‐1 have mainly been …
Dual effects of bryostatin-1 on spatial memory and depression
MK Sun, DL Alkon - European journal of pharmacology, 2005 - Elsevier
Dementia and depression are clinical symptoms commonly associated in patients. Emerging
evidence suggests that the two diseases share many profiles in their development and …
evidence suggests that the two diseases share many profiles in their development and …
Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor …
K Fukuhara, K Ishikawa, S Yasuda, Y Kishishita… - Cellular and molecular …, 2012 - Springer
Neuropathic pain concurrent with mood disorder from peripheral nerve injury is a serious
clinical problem that significantly affects quality of life. Recent studies have suggested that a …
clinical problem that significantly affects quality of life. Recent studies have suggested that a …
Protein kinase C activators as synaptogenic and memory therapeutics
MK Sun, DL Alkon - Archiv der Pharmazie: An International …, 2009 - Wiley Online Library
The last decade has witnessed a rapid progress in understanding of the molecular cascades
that may underlie memory and memory disorders. Among the critical players, activity of …
that may underlie memory and memory disorders. Among the critical players, activity of …
Open space swimming test to index antidepressant activity
MK Sun, DL Alkon - Journal of neuroscience methods, 2003 - Elsevier
Depression is characterized by a lack of “motivation” rather than a lack of “physical space” to
move around. This study was designed to evaluate predictivity of an open space swimming …
move around. This study was designed to evaluate predictivity of an open space swimming …
Induced depressive behavior impairs learning and memory in rats
MK Sun, DL Alkon - Neuroscience, 2004 - Elsevier
While it is generally accepted that cognitive processes such as learning and memory are
affected by emotion, the impact of depression on learning and memory has rarely been …
affected by emotion, the impact of depression on learning and memory has rarely been …
Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor
S Yasuda, M Yoshida, H Yamagata, Y Iwanaga… - Cellular and molecular …, 2014 - Springer
Depression-like behavior is often complicated by chronic pain. Antidepressants including
imipramine (IMI) are widely used to treat chronic pain, but the mechanisms are not fully …
imipramine (IMI) are widely used to treat chronic pain, but the mechanisms are not fully …
The use of conversational laughter by an individual with dementia
While laughter has been shown to play a significant role in any social interaction; its
conversational usage by a person with dementia has rarely been investigated. This paper …
conversational usage by a person with dementia has rarely been investigated. This paper …
p-Chloro-diphenyl diselenide, an organoselenium compound, with antidepressant-like and memory enhancer actions in aging male rats
The aim of this study was to evaluate the protective effects of p-chloro-diphenyl diselenide (p-
ClPhSe) 2 on depressant-like action and cognitive impairment caused by aging in male rats …
ClPhSe) 2 on depressant-like action and cognitive impairment caused by aging in male rats …
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs
A Kling, UEW Lange, H Mack, MHM Bakker… - Bioorganic & medicinal …, 2005 - Elsevier
Novel 5-HT1 autoreceptor ligands based on the N-4-aryl-piperazinyl-N′-ethyl-5, 6, 7, 8-
tetrahydropyrido [4′, 3′: 4, 5] thieno [2, 3-d] pyrimidin-4 (3H)-one core are described …
tetrahydropyrido [4′, 3′: 4, 5] thieno [2, 3-d] pyrimidin-4 (3H)-one core are described …