Trends in insulin resistance: insights into mechanisms and therapeutic strategy
M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
The role of miRNAs in insulin resistance and diabetic macrovascular complications–A review
Diabetes is the most prevalent metabolic disturbance disease and has been regarded
globally as one of the principal causes of mortality. Diabetes is accompanied by several …
globally as one of the principal causes of mortality. Diabetes is accompanied by several …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
miRNAs as cornerstones in adipogenesis and obesity
In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …
significantly associated with serious co-morbidities that could decrease life quality and even …
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
G Xourafa, M Korbmacher, M Roden - Nature Reviews Endocrinology, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut
Objective Ample evidence exists for the role of abnormal gut microbiota composition and
increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in …
increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in …
Signaling pathways and targeted therapies for psoriasis
J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …
individuals, health systems, and society worldwide. With the immunological pathologies and …
ncRNA-mediated fatty acid metabolism reprogramming in HCC
K Xu, P Xia, X Chen, W Ma, Y Yuan - Trends in Endocrinology & Metabolism, 2023 - cell.com
The challenges of hepatocellular carcinoma (HCC) pathogenesis, diagnosis, treatment, and
prognosis evaluation are obvious. Hepatocyte-specific fatty acid (FA) metabolic …
prognosis evaluation are obvious. Hepatocyte-specific fatty acid (FA) metabolic …