Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

L Yang, P Yang, GYH Lip, J Ren - Trends in pharmacological sciences, 2023 - cell.com
Copper (Cu) homeostasis is gaining increasing attention in human health as both Cu
overload and deficiency evokes pathological changes including cardiovascular diseases …

Fighting obesity-related micronutrient deficiencies through biofortification of agri-food crops with sustainable fertilization practices

CE Guardiola-Márquez, MT Santos-Ramírez… - Plants, 2022 - mdpi.com
Obesity is a critical medical condition worldwide that is increasingly involved with nutritional
derangements associated with micronutrient deficiencies, including iron, zinc, calcium …

Altered metal homeostasis associates with inflammation, oxidative stress, impaired glucose metabolism, and dyslipidemia in the crosstalk between childhood obesity …

Á González-Domínguez, M Millán-Martínez… - Antioxidants, 2022 - mdpi.com
Metals are redox-active substances that participate in central biological processes and may
be involved in a multitude of pathogenic events. However, considering the inconsistencies …

Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity

Á González‐Domínguez, J Domínguez‐Riscart… - …, 2023 - Wiley Online Library
Although puberty is known to influence obesity progression, the molecular mechanisms
underlying the role of sexual maturation in obesity‐related complications remains largely …

Overnutrition is a risk factor for iron, but not for zinc or vitamin A deficiency in children and young people: a systematic review and meta-analysis

X Tan, PY Tan, YY Gong, JB Moore - BMJ Global Health, 2024 - gh.bmj.com
Introduction Traditionally associated with undernutrition, increasing evidence suggests
micronutrient deficiencies can coexist with overnutrition. Therefore, this work aimed to …

Single and combined associations of plasma and urine essential trace elements (Zn, Cu, Se, and Mn) with cardiovascular risk factors in a mediterranean population

R Barragán, C Sánchez-González, P Aranda, JV Sorlí… - Antioxidants, 2022 - mdpi.com
Trace elements are micronutrients that are required in very small quantities through diet but
are crucial for the prevention of acute and chronic diseases. Despite the fact that initial …

Overweight and obesity are positively associated with serum copper levels in Mexican schoolchildren

M Vazquez-Moreno, M Sandoval-Castillo… - Biological trace element …, 2023 - Springer
Due to its relationship with oxidative stress and inflammation responses, obesity and its
cardiometabolic implications have been related with serum copper (Cu). Hence, we …

Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis

JG Ortega-Avila, H García-Muñoz… - Biology of sex …, 2022 - Springer
Background Differences in adolescents and adults by sex in blood levels of leptin and
adiposity have been described; however, it is not yet clear if these differences arise from the …

Childhood Obesity and Essential Micronutrients: Insights from India's Comprehensive National Nutrition Survey (2016–18)

M Verma, A Aditi, N Kapoor, P Sharma, M Kakkar… - Diabetes Therapy, 2023 - Springer
Introduction Based on the long-term impact of childhood obesity, there is a compelling need
to assess the burden of obesity and micronutrient deficiency and the interactions between …

Association between childhood obesity, trace elements, and heavy metals: Recent discoveries and future perspectives

Á González‐Domínguez, L Jurado‐Sumariva… - Obesity …, 2024 - Wiley Online Library
Trace elements and heavy metals play pivotal roles in health status by regulating a myriad of
vital biological functions. Abnormal metal homeostasis has been linked to a constellation of …