The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

Recent evidence revealed extra skeleton activity of vitamin D, including prevention from
cardiometabolic diseases and cancer development as well as anti-inflammatory properties …

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

ABSTRACT Abbreviations: A1C= hemoglobin A1C AACE= American Association of Clinical
Endocrinologists ACCORD= Action to Control Cardiovascular Risk in Diabetes ACCORD …