Background The expression of interleukin-1–receptor antagonist is reduced in pancreatic
islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Nearly a quarter of older adults in the US have type 2 diabetes, and this population is
continuing to increase with the aging of the population. Older adults are at high risk for the …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is
probably the main form of β-cell death in both forms of the disease. It has been suggested …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …

Type 2 diabetes is a progressive dis-ease in which the risks of myocardial infarction, stroke,
microvascular events, and mortality are all strongly associated with hyperglycemia (1). The …

During pregnancy, the energy requirements of the fetus impose changes in maternal
metabolism. Increasing insulin resistance in the mother maintains nutrient flow to the …

The proportions of people with type 2 diabetes and obesity have increased throughout Asia,
and the rate of increase shows no sign of slowing. People in Asia tend to develop diabetes …

Pancreatic cancer is an aggressive malignancy with a poor prognosis. The disease and its
treatment can cause significant nutritional impairments that often adversely impact patient …