Purpose: Cancer is a multigene disease which arises as a result of mutational and
epigenetic changes coupled with activation of complex signaling networks. The use of …

Multiple studies have demonstrated the utility of chromosomal microarray (CMA) testing to
identify clinically significant copy number alterations (CNAs) and copy-neutral loss-of …

MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast
to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast …

Higher-risk myelodysplastic syndromes (MDS) are defined by patients who fall into higher-
risk group categories in the original or revised International Prognostic Scoring System …

A hallmark of acute promyelocytic leukemia (APL) is altered nuclear architecture, with
disruption of promyelocytic leukemia (PML) nuclear bodies (NBs) mediated by the PML …

Myelodysplastic syndromes (MDS) are a family of myeloid cancers with diverse genotypes
and phenotypes characterized by ineffective haematopoiesis and risk of transformation to …

Background Molecular interrogation of genetic information has transformed our
understanding of disease and is now routinely integrated into the workup and monitoring of …

Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal
hematopoietic disorders. Metaphase cytogenetics has been the gold standard for genetic …

Background. Myelodysplastic syndromes (MDS) represent a heterogeneous group of
premalignant hematologic disorders characterized by ineffective hematopoiesis, peripheral …

Background: The purpose of the present study was to evaluate the detection rate of genomic
aberrations in haematological malignancies using oligobased array-CGH (oaCGH) analysis …