The increase in the life expectancy of patients with renal cell carcinoma (RCC) in the last
decade is due to changes that have occurred in the area of preclinical studies …

Abstract Background Combinations of PD-1/PD-L1 immune checkpoint inhibitors (ICI) with
VEGFR-TKIs as first-line therapy significantly improve outcomes of metastatic renal cell …

Immune checkpoint inhibitors (ICIs) have advanced the field of cancer immunotherapy in
patients by sustaining effector immune cell activity within the tumor microenvironment …

Abstract Polo-like kinase 1 (Plk1) expression is inversely correlated with survival
advantages in many cancers. However, molecular mechanisms that underlie Plk1 …

Purpose 6-Gingerol, a major biochemical and pharmacological active ingredient of ginger,
has shown anti-inflammatory and antitumor activities against various cancers. Searching for …

Introduction Recent trials have suggested predictive biomarkers in advanced clear-cell renal
cell carcinoma (accRCC): International Metastatic RCC Database Consortium (IMDC) good …

Tumor vessels provide essential paths for tumor cells to escape from the primary tumor and
form metastatic foci in distant organs. The vessel targeting strategy has been widely used as …

Long non-coding RNA metastasis associated with lung adenocarcinoma transcript 1
(MALAT1) contributes to chemotherapy resistance in some cancers, but the role of MALAT1 …

The present study involves design and synthesis of five series of 6-bromo-2-(pyridin-3-yl)-4-
substituted quinazolines 9a-l, 11a-e, 13a-c, 14a-f and 15a-e. Candidates 9a-l and 11a-e …

Objectives To investigate the efficacy and safety of first‐line nivolumab plus ipilimumab for
patients treated with metastatic renal cell carcinoma. Methods We retrospectively evaluated …