Global burden of sleep‐disordered breathing and its implications

MM Lyons, NY Bhatt, AI Pack, UJ Magalang - Respirology, 2020 - Wiley Online Library
One‐seventh of the world's adult population, or approximately one billion people, are
estimated to have OSA. Over the past four decades, obesity, the main risk factor for OSA, has …

Obstructive sleep apnea and comorbidities: a dangerous liaison

MR Bonsignore, P Baiamonte, E Mazzuca… - Multidisciplinary …, 2019 - Springer
Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes

DR Mazzotti, BT Keenan, DC Lim… - American journal of …, 2019 - atsjournals.org
Rationale: Symptom subtypes have been described in clinical and population samples of
patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes have …

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias

AI Pack, UJ Magalang, B Singh, ST Kuna, BT Keenan… - Sleep, 2021 - academic.oup.com
Three recent randomized control trials (RCTs) found that treatment of obstructive sleep
apnea (OSA) with continuous positive airway pressure (CPAP) did not reduce rates of future …

The sleep apnea-specific hypoxic burden predicts incident heart failure

A Azarbarzin, SA Sands, L Taranto-Montemurro… - Chest, 2020 - Elsevier
Background Heart failure (HF) is a leading cause of morbidity and mortality and although it is
linked to sleep apnea, which physiological stressors most strongly associate with incident …

Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine

A Zinchuk, HK Yaggi - Chest, 2020 - Elsevier
Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea

SA Sands, BA Edwards, PI Terrill… - American journal of …, 2018 - atsjournals.org
Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient's own phenotypic causes (“traits”) if a clinically applicable approach were …

Apnea–hypopnea event duration predicts mortality in men and women in the sleep heart health study

MP Butler, JT Emch, M Rueschman… - American journal of …, 2019 - atsjournals.org
Rationale: Obstructive sleep apnea is a risk factor for mortality, but its diagnostic metric—the
apnea–hypopnea index—is a poor risk predictor. The apnea–hypopnea index does not …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

CPAP therapy termination rates by OSA phenotype: a French nationwide database analysis

JL Pépin, S Bailly, P Rinder, D Adler, D Szeftel… - Journal of clinical …, 2021 - mdpi.com
The nationwide claims data lake for sleep apnoea (ALASKA)—real-life data for
understanding and increasing obstructive sleep apnea (OSA) quality of care study …