Sleep apnea heterogeneity, phenotypes, and cardiovascular risk. Implications for trial design and precision sleep medicine

A Zinchuk, HK Yaggi - American journal of respiratory and critical …, 2019 - atsjournals.org
Obstructive sleep apnea (OSA) affects 25 million adults in the United States and is linked to
major causes of morbidity and mortality, including coronary heart disease, heart failure (HF) …

Sleep disordered breathing as a cause and consequence of stroke: a review of pathophysiological and clinical relationships

P Tanayapong, ST Kuna - Sleep Medicine Reviews, 2021 - Elsevier
Stroke is the leading cause of death and disability globally. Sleep disordered breathing
(SDB), a potentially modifiable risk factor of stroke, is highly prevalent in stroke survivors …

Self-reported sleepiness and not the apnoea hypopnoea index is the best predictor of sleepiness-related accidents in obstructive sleep apnoea

P Philip, S Bailly, M Benmerad, JA Micoulaud-Franchi… - Scientific reports, 2020 - nature.com
To evaluate the value of apnoea+ hypopnoea index versus self-reported sleepiness at the
wheel in anticipating the risk of sleepiness-related accidents in patients referred for …

Polysomnographic phenotyping of obstructive sleep apnea and its implications in mortality in Korea

JW Kim, TB Won, CS Rhee, YM Park, IY Yoon… - Scientific reports, 2020 - nature.com
Conventionally, apnea–hypopnea index (AHI) is used to define and categorize the severity
of obstructive sleep apnea. However, routine polysomnography (PSG) includes multiple …

Nonfatal and fatal cardiovascular disease events in CPAP compliant obstructive sleep apnea patients

M Myllylä, A Hammais, M Stepanov, U Anttalainen… - Sleep and …, 2019 - Springer
Purpose Obstructive sleep apnea (OSA) is suggested to predispose to cardiovascular
disease (CVD) events. It is uncertain whether compliance to continuous positive airway …

New metrics from polysomnography: precision medicine for OSA interventions

J Guo, Y Xiao - Nature and Science of Sleep, 2023 - Taylor & Francis
Obstructive sleep apnea (OSA) is a highly preventable disease accompanied by multiple
comorbid conditions. Despite the well-established cardiovascular and neurocognitive …

Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study

T Kendzerska, RS Leung, CL Atzema, G Chandy… - Sleep medicine, 2020 - Elsevier
Abstract Objective/Background Evidence on sex differences in the association between
obstructive sleep apnea (OSA) and cardiovascular outcomes is limited and controversial …

Obstructive sleep apnoea in acute coronary syndrome

W Randerath, MR Bonsignore… - European Respiratory …, 2019 - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) syndrome affects about 13% of the male and 7–9% of the
female population. Hypoxia, oxidative stress and systemic inflammation link OSA and …

Hypoxemic features of obstructive sleep apnea and the risk of mortality: a cluster analysis

G Labarca, J Jorquera, J Dreyse, C Salas… - Sleep and Breathing, 2021 - Springer
Introduction Patients with moderate to severe obstructive sleep apnea (OSA) have an
increased risk of cardiovascular comorbidities and mortality. Although different subtypes of …

Obstructive sleep apnea in patients with chronic obstructive pulmonary disease: facts and perspectives

A Lurie, N Roche - COPD: Journal of Chronic Obstructive …, 2021 - Taylor & Francis
The co-occurrence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary
disease (COPD) in the same patient, named the overlap syndrome (OS), was first described …