Pain management is a crucial part in Sickle Cell Disease treatment. Accurate pain
assessment is the first stage in pain management. However, pain is a subjective experience …

The anemia of sickle cell disease is associated with a severe inflammatory vasculopathy
and endothelial dysfunction, which leads to painful and life-threatening clinical …

Polymerization of the sickle hemoglobin (HbS) is a key determinant of sickle cell disease
(SCD), an inherited blood disorder. Fetal hemoglobin (HbF) is a major modulator of the …

Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide
distribution. Growing evidence suggests a possible involvement of complement activation in …

As most patients with sickle cell disease (SCD) do not have access to curative therapies, the
availability of drug therapies that can modify disease severity remains highly desirable …

Introduction Allogeneic hematopoietic stem cell transplant (HSCT) and gene therapy (GT)
are two potentially curative approaches for sickle cell disease (SCD), but they have never …

We aimed to investigate the clinical and genetic predictors of painful vaso‐occlusive crises
(VOC) in sickle cell disease (SCD) in Cameroon. Socio‐demographics, clinical …

Objective: Sickle cell disease is a lifelong illness affecting millions of people globally, but
predominantly burdensome in sub-Saharan Africa, where most affected children do not live …

Sickle cell disease (SCD) places a heavy burden on a global and increasing population
predominantly resident in resource-poor and developing countries. Progress continues to be …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …