Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Effect of physical activity/exercise on oxidative stress and inflammation in muscle and vascular aging

M El Assar, A Álvarez-Bustos, P Sosa, J Angulo… - International Journal of …, 2022 - mdpi.com
Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases

GD Albano, RP Gagliardo, AM Montalbano, M Profita - Antioxidants, 2022 - mdpi.com
Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

[HTML][HTML] Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

Y Wang, S Liao, Z Pan, S Jiang, J Fan, S Yu… - Free Radical Biology …, 2022 - Elsevier
Background Redox imbalance is an vital mechanism for COPD. At present, insufficient
researches have been conducted on the protective effect of hydrogen sulfide (H 2 S) on PM …

Oxidative stress and inflammation in acute and chronic lung injuries

FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

T Liu, YF Lv, JL Zhao, QD You, ZY Jiang - Free Radical Biology and …, 2021 - Elsevier
The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Redox signaling at the crossroads of human health and disease

J Zuo, Z Zhang, M Luo, L Zhou, EC Nice, W Zhang… - MedComm, 2022 - Wiley Online Library
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Current insights into atopic march

M Tsuge, M Ikeda, N Matsumoto, T Yorifuji… - Children, 2021 - mdpi.com
The incidence of allergic diseases is increasing, and research on their epidemiology,
pathophysiology, and the prevention of onset is urgently needed. The onset of allergic …