The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Blood–brain barrier endothelial cells in neurodegenerative diseases: signals from the “barrier”
Y Yuan, J Sun, Q Dong, M Cui - Frontiers in Neuroscience, 2023 - frontiersin.org
As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …
Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors
NT Markov, CA Lindbergh… - Proceedings of the …, 2022 - National Acad Sciences
Aging is characterized by a progressive loss of brain volume at an estimated rate of 5% per
decade after age 40. While these morphometric changes, especially those affecting gray …
decade after age 40. While these morphometric changes, especially those affecting gray …
Peripheral blood amyloid-β involved in the pathogenesis of Alzheimer's disease via impacting on peripheral innate immune cells
M Shi, F Chu, F Zhu, J Zhu - Journal of Neuroinflammation, 2024 - Springer
A key pathological factor of Alzheimer's disease (AD), the most prevalent form of age-related
dementia in the world, is excessive β-amyloid protein (Aβ) in extracellular aggregation in the …
dementia in the world, is excessive β-amyloid protein (Aβ) in extracellular aggregation in the …
White matter injury across neurodegenerative disease
Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …
(CNS), are active players in shaping neuronal circuitry and function. It has become …
Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma
Repetitive physical insults to the head, including those that elicit mild traumatic brain injury
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …
The innate immune response in tauopathies
AM Johnson, JR Lukens - European journal of immunology, 2023 - Wiley Online Library
Tauopathies, which include frontotemporal dementia, Alzheimer's disease, and chronic
traumatic encephalopathy, are a class of neurological disorders resulting from pathogenic …
traumatic encephalopathy, are a class of neurological disorders resulting from pathogenic …
A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice
G Wang, S Jin, J Liu, X Li, P Dai, Y Wang… - National Science …, 2023 - academic.oup.com
Neuroimmune connections have been revealed to play a central role in neurodegenerative
diseases (NDs). However, the mechanisms that link the central nervous system (CNS) and …
diseases (NDs). However, the mechanisms that link the central nervous system (CNS) and …
A vision of 14 T MR for fundamental and clinical science
S Bates, SO Dumoulin, PJM Folkers… - … Resonance Materials in …, 2023 - Springer
Objective We outline our vision for a 14 Tesla MR system. This comprises a novel whole-
body magnet design utilizing high temperature superconductor; a console and associated …
body magnet design utilizing high temperature superconductor; a console and associated …
Single-cell multiomic analysis reveals the involvement of type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss
N Fernando, J Gopalakrishnan, A Behensky, L Reich… - BioRxiv, 2023 - biorxiv.org
Alzheimer's disease (AD) is the leading cause of dementia worldwide, but there are limited
therapeutic options and no current cure. While the involvement of microglia in AD has been …
therapeutic options and no current cure. While the involvement of microglia in AD has been …