The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023 - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Blood–brain barrier endothelial cells in neurodegenerative diseases: signals from the “barrier”

Y Yuan, J Sun, Q Dong, M Cui - Frontiers in Neuroscience, 2023 - frontiersin.org
As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors

NT Markov, CA Lindbergh… - Proceedings of the …, 2022 - National Acad Sciences
Aging is characterized by a progressive loss of brain volume at an estimated rate of 5% per
decade after age 40. While these morphometric changes, especially those affecting gray …

Peripheral blood amyloid-β involved in the pathogenesis of Alzheimer's disease via impacting on peripheral innate immune cells

M Shi, F Chu, F Zhu, J Zhu - Journal of Neuroinflammation, 2024 - Springer
A key pathological factor of Alzheimer's disease (AD), the most prevalent form of age-related
dementia in the world, is excessive β-amyloid protein (Aβ) in extracellular aggregation in the …

White matter injury across neurodegenerative disease

LK Festa, JB Grinspan, KL Jordan-Sciutto - Trends in Neurosciences, 2024 - cell.com
Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …

Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma

C Ye, JA Behnke, KR Hardin, JQ Zheng - Frontiers in Neuroscience, 2023 - frontiersin.org
Repetitive physical insults to the head, including those that elicit mild traumatic brain injury
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …

The innate immune response in tauopathies

AM Johnson, JR Lukens - European journal of immunology, 2023 - Wiley Online Library
Tauopathies, which include frontotemporal dementia, Alzheimer's disease, and chronic
traumatic encephalopathy, are a class of neurological disorders resulting from pathogenic …

A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

G Wang, S Jin, J Liu, X Li, P Dai, Y Wang… - National Science …, 2023 - academic.oup.com
Neuroimmune connections have been revealed to play a central role in neurodegenerative
diseases (NDs). However, the mechanisms that link the central nervous system (CNS) and …

A vision of 14 T MR for fundamental and clinical science

S Bates, SO Dumoulin, PJM Folkers… - … Resonance Materials in …, 2023 - Springer
Objective We outline our vision for a 14 Tesla MR system. This comprises a novel whole-
body magnet design utilizing high temperature superconductor; a console and associated …

Single-cell multiomic analysis reveals the involvement of type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

N Fernando, J Gopalakrishnan, A Behensky, L Reich… - BioRxiv, 2023 - biorxiv.org
Alzheimer's disease (AD) is the leading cause of dementia worldwide, but there are limited
therapeutic options and no current cure. While the involvement of microglia in AD has been …