Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview
J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment
JAR Salvador, AS Leal, AS Valdeira… - European Journal of …, 2017 - Elsevier
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of
biological activities. Among them, the anticancer and anti-inflammatory activities are the …
biological activities. Among them, the anticancer and anti-inflammatory activities are the …
[HTML][HTML] From plant compounds to botanicals and back: A current snapshot
A Durazzo, L D'Addezio, E Camilli, R Piccinelli… - Molecules, 2018 - mdpi.com
This work aims at giving an updated picture of the strict interaction between main plant
biologically active compounds and botanicals. The main features of the emerging class of …
biologically active compounds and botanicals. The main features of the emerging class of …
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research
J Hodon, L Borkova, J Pokorny, A Kazakova… - European journal of …, 2019 - Elsevier
Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …
The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities
JN del Hierro, T Herrera, T Fornari, G Reglero… - Journal of Functional …, 2018 - Elsevier
Saponins are bioactive compounds of increasing interest. The events that take place during
digestion are highly related to their bioactivities, because saponins are poorly absorbed and …
digestion are highly related to their bioactivities, because saponins are poorly absorbed and …
[HTML][HTML] Pentacyclic triterpenoids with nitrogen-containing heterocyclic moiety, privileged hybrids in anticancer drug discovery
Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …
commonly found in plants as secondary metabolites. The wide range of biological activities …
[HTML][HTML] Recent developments in the functionalization of betulinic acid and its natural analogues: a route to new bioactive compounds
JLC Sousa, CSR Freire, AJD Silvestre, AMS Silva - Molecules, 2019 - mdpi.com
Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …
Carboxylesterase inhibitors: an update
LW Zou, Q Jin, DD Wang, QK Qian… - Current medicinal …, 2018 - ingentaconnect.com
Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
[HTML][HTML] Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology
W Peng, Y Liu, M Hu, M Zhang, J Yang… - Revista Brasileira de …, 2019 - SciELO Brasil
Abstract Toona sinensis (Juss.) M. Roem, Meliaceae, a deciduous plant native to eastern
and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was …
and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was …
[HTML][HTML] Phenolic compounds and triterpenes in different olive tissues and olive oil by-products, and cytotoxicity on human colorectal cancer cells: The case of frantoio …
Phenolic and triterpenoid compounds of the olive tree are recognized as having a key role in
health promotion, thanks to their multiple protective actions in humans. To expand the …
health promotion, thanks to their multiple protective actions in humans. To expand the …