Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

We conducted this meta-analysis of double-blind randomized placebo-controlled trials to
estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially …

A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …

Introduction Neurodegeneration is the term describing the death of neurons both in the
central nervous system and periphery. When affecting the central nervous system, it is …

Inflammation is a natural host defensive process that is largely regulated by macrophages
during the innate immune response. Mitogen‐activated protein kinases (MAPKs) are proline …

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory
demyelination and neurodegeneration within the CNS. This damage of CNS structures …

Recent research has provided strong evidence for the role of the commensal gut microbiota
in brain function and behaviour. Many potential pathways are involved in this bidirectional …

Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …

Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …