Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Stroke is one of the leading causes of death and long-term disability worldwide. More than
80% of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question …

Background Mitophagy plays a critical role in cerebral ischemia/reperfusion by timely
removal of dysfunctional mitochondria. In mammals, PINK1/Parkin is the most classic …

Background Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a
critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is …

Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in
the lysosome, thus serving an important role in cellular homeostasis and protection against …

Abstract Background/Purpose: Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (R.
crenulate), a famous and characteristic Tibetan medicine, has been demonstrated to exert …

Cerebral ischemia/reperfusion (I/R) injury is caused by blood flow recovery after an ischemic
stroke, and effective treatments targeting I/R injury are still insufficient. Oxidative stress is …

Ethnopharmacological relevance Rhodiola crenulata is clinically used to combat hypobaric
hypoxia brain injury at high altitude with the function of invigorating Qi and promoting blood …

In the past few years, emerging evidence established persistent oxidative stress to be a key
player in the pathogenesis of polycystic ovary syndrome (PCOS). Particularly, it damages …

Background Toll‐like receptor 4 (TLR4) participates in the initiation of neuroinflammation in
various neurological diseases, including central nervous system injuries. NLR family pyrin …