[HTML][HTML] COPD and the gut-lung axis: the therapeutic potential of fibre

A Vaughan, ZA Frazer, PM Hansbro… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Current management strategies for chronic obstructive pulmonary disease (COPD)
incorporate a step-wise, multidisciplinary approach to effectively manage patient symptoms …

[HTML][HTML] Role of lung microbiome in innate immune response associated with chronic lung diseases

KR Paudel, V Dharwal, VK Patel, I Galvao… - Frontiers in …, 2020 - frontiersin.org
Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung
fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the …

[PDF][PDF] Role of oxidative stress in the pathogenesis of COPD

F Nucera, S Mumby, KR Paudel, V Dharwal… - Minerva …, 2022 - opus.lib.uts.edu.au
Chronic inhalation of cigarette smoke is a prominent cause of chronic obstructive pulmonary
disease (COPD) and provides an important source of exogenous oxidants. In addition …

[HTML][HTML] The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory Research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Pulmonary drug delivery applications of natural polysaccharide polymer derived nano/micro-carrier systems: A review

A Balde, SK Kim, S Benjakul, RA Nazeer - International Journal of …, 2022 - Elsevier
Respiratory distress syndrome and pneumothorax are the foremost causes of death as a
result of the changing lifestyle and increasing air pollution. Numerous approaches have …

[HTML][HTML] Risk factors for immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer

Y Chao, J Zhou, S Hsu, N Ding, J Li… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitors (ICIs) have led to dramatic improvements in
survival a subset of patients with non-small cell lung cancer (NSCLC); however, they have …

Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies

Y Cui, M Pan, J Ma, X Song, W Cao… - Molecular and cellular …, 2021 - Springer
Mitochondria have various cellular functions, including ATP synthesis, calcium homeostasis,
cell senescence, and death. Mitochondrial dysfunction has been identified in a variety of …

Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

DA Skerrett‐Byrne, EG Bromfield, HC Murray… - …, 2021 - Wiley Online Library
Background and objective Chronic obstructive pulmonary disease (COPD) is the third
leading cause of illness and death worldwide. Current treatments aim to control symptoms …

Recent advances in experimental animal models of lung cancer

V Malyla, KR Paudel, SD Shukla… - Future Medicinal …, 2020 - Future Science
Conclusion Collectively, the analysis of genetically modified and chemically induced animal
models of lung cancer has progressed the understanding of lung cancer pathogenesis …

[HTML][HTML] Mitochondria-targeted antioxidants as a therapeutic strategy for chronic obstructive pulmonary disease

LH Fairley, S Das, V Dharwal, N Amorim, KJ Hegarty… - Antioxidants, 2023 - mdpi.com
Oxidative stress is a major hallmark of COPD, contributing to inflammatory signaling,
corticosteroid resistance, DNA damage, and accelerated lung aging and cellular …