Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Sensory hair cells of the inner ear are exposed to continuous mechanical stress, causing
damage over time. The maintenance of hair cells is further challenged by damage from a …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Acquired sensorineural hearing loss is one of the most prevalent chronic diseases, and
aging and acoustic overexposure are common contributors. Decades of study in animals …

The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner
ear generally leads to permanent hearing loss in humans. Here, we present that …

Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …

Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

Hair cells are sensory receptors for the auditory and vestibular system in vertebrates. The
transcription factor Atoh1 is both necessary and sufficient for the differentiation of hair cells …

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …