An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

The cochlea consists of multiple types of cells, including hair cells, supporting cells and
spiral ganglion neurons, and is responsible for converting mechanical forces into electric …

Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in
regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many …

Age-related hearing loss in humans is characterized by progressive loss of threshold
sensitivity, especially at high frequencies. A multivariable regression of histopathological …

Utricular hair cells (HCs) are mechanoreceptors required for vestibular function. After
damage, regeneration of mammalian utricular HCs is limited and regenerated HCs appear …

The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural
hearing loss. This study aimed to promote the regeneration of sensory hair cells in the …

The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of
hearing. In contrast, the adult vestibular system can produce new hair cells in response to …

Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …

Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss.
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …

Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells
transduce mechanical stimuli into electrical signals, whereas the stria is responsible for …