The progressive, late-onset, nonsyndromic, sensorineural hearing loss (PNSHL) is the most
common cause of sensory impairment globally, with presbycusis affecting greater than a …

MicroRNAs (miRNAs) are a category of small RNAs that modulate levels of proteins via post-
transcriptional inhibition. Currently, a standard strategy to overexpress miRNAs is as mature …

Despite impressive technical progress in the field of conventional hearing aids and
implantable hearing systems, the hopes for the treatment of inner ear diseases such as …

Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models
of deafness. However, to the best of our knowledge, there is no report on the establishment …

Hearing loss is currently an incurable degenerative disease characterized by a paucity of
hair cells (HCs), which cannot be spontaneously replaced in mammals. Recent …

Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of
adenovirus-mediated Atoh1 overexpression has mainly focused on the rat lesser epithelial …

Background Stem cells therapy of hearing loss is a challenging field due to lacking self-
regenerative capacity of cochlea. Harderian gland of guinea pigs was thought to harbour a …

Arbetsmiljöverket har fått i uppdrag av regeringen att informera och sprida kunskap om
områden av betydelse för arbetsmiljön. Under kommande år publiceras därför ett flertal …

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix transcription factor that is essential for
inner ear hair cell differentiation. Previous studies have reported that Atoh1 gene transfer …