When hearing fails, electrical cochlear implants (eCIs) provide the brain with auditory
information. One important bottleneck of CIs is the poor spectral selectivity that results from …

As biomolecular approaches for hearing restoration in profound sensorineural hearing loss
evolve, they will be applied in conjunction with or instead of cochlear implants. An …

Cochlear implantation has become the standard of care for hearing loss not amenable to
amplification by bypassing the structures of the cochlea and stimulating the spiral ganglion …

The first microbial rhodopsin, a light-driven proton pump bacteriorhodopsin from
Halobacterium salinarum (Hs BR), was discovered in 1971. Since then, this seven-α-helical …

Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future
alternative to electrical stimulation used in current cochlear implants. Here, we employed …

When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct
stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than …

Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to
the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration …

Key points Loss of the calcium sensor otoferlin disrupts neurotransmission from inner hair
cells. Central auditory nuclei are functionally denervated in otoferlin knockout mice (Otof …

Objective: The primary aim of the study was to explore whether reduced spread of electrical
field is observed after partial or subtotal cochleoectomy and cochlear implantation compared …

Research on type 1 rhodopsins spans now a history of 50 years. Originally, just archaeal ion
pumps and sensors have been discovered. However, with modern genetic techniques and …