Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve,
characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearing …

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

5. Mechanisms of Transduction and Excitation in the Cochlea.. 1 1 2 A. Introduction.......... 1 1
2 B. The cytoskeleton of the transducer region..... 1 1 3 C. Mechanisms of transduction....... 1 …

Whereas the mechanisms underlying hearing impairment in USH patients are being
unraveled, showing in particular that USH1 proteins are involved in the shaping of the hair …

Congenital hearing disorders affect millions of children worldwide and can significantly
impact acquisition of speech and language. Efforts to identify the developmental genetic …

Congenital hearing impairment affects nearly 1 in every 1000 live births and is the most
frequent birth defect in developed societies. Hereditary types of hearing loss account for …

Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary
deafness, and different viral serotypes, promoters and transduction pathways can influence …

Autosomal dominant non-syndromic hearing loss (ADNSHL) displays gene-specific
progression of hearing loss, which is amenable to sequential audioprofiling. We sought to …

Drug delivery to the inner ear is an ideal method to treat a wide variety of otologic conditions.
A broad range of potential applications is just beginning to be explored. New approaches …

The highly compartmentalized anatomy of the ear aggravates drug delivery, which is used to
combat hearing-related diseases. Novel nanosized drug vehicles are thought to overcome …