Background Cardiovascular disease, which includes coronary artery disease, stroke and
peripheral vascular disease, is a leading cause of death worldwide. Homocysteine is an …

An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

In 1969, McCully made the clinical observation linking elevated plasma homocyst (e) ine
concentrations with vascular disease. 1 He reported autopsy evidence of extensive arterial …

Objective.—To describe the distribution of plasma homocysteine concentrations in an
elderly population and to analyze the relationship between homocysteine level and intake of …

Context.—Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular
disease, but the strength of the relationship and the interaction of plasma homocysteine with …

Background Elevated plasma homocysteine levels are a risk factor for coronary heart
disease, but the prognostic value of homocysteine levels in patients with established …

Total homocysteine is defined as the sum of all homocysteine species in plasma/serum,
including free and protein-bound forms. In the present review, we compare and evaluate …

This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a
particular emphasis on how it is, or may be, involved in many disease processes. Folic acid …

Objective.—To estimate the relations between established cardiovascular risk factors and
total homocysteine (tHcy) in plasma. Design.—Health examination survey by the Norwegian …

Abstract purpose: Patients with cobalamin (vitamin B12) deficiency usually lack many of the
classic features of severe megaloblastic anemia; because of the low diagnostic specificity of …