Clonal hematopoiesis: mechanisms driving dominance of stem cell clones
GA Challen, MA Goodell - Blood, The Journal of the American …, 2020 - ashpublications.org
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
Somatic mutations in “benign” disease
S Mustjoki, NS Young - New England Journal of Medicine, 2021 - Mass Medical Soc
Somatic Mutations in “Benign” Disease DNA mutations occur in nearly every tissue
throughout the human life span and accumulate at various rates in different tissues …
throughout the human life span and accumulate at various rates in different tissues …
Association of clonal hematopoiesis of indeterminate potential with worse kidney function and anemia in two cohorts of patients with advanced chronic kidney disease
C Vlasschaert, AJM McNaughton… - Journal of the …, 2022 - journals.lww.com
Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …
The impact of inflammation-induced tumor plasticity during myeloid transformation
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …
Clonal hematopoiesis and risk of incident lung cancer
PURPOSE To prospectively examine the association between clonal hematopoiesis (CH)
and subsequent risk of lung cancer. METHODS Among 200,629 UK Biobank (UKBB) …
and subsequent risk of lung cancer. METHODS Among 200,629 UK Biobank (UKBB) …
Distinct clinico-molecular arterial and venous thrombosis scores for myeloproliferative neoplasms risk stratification
H Pasquer, R Daltro de Oliveira, L Vasseur… - Leukemia, 2024 - nature.com
Current recommended risk scores to predict thrombotic events associated with
myeloproliferative neoplasms (MPN) do not discriminate between arterial and venous …
myeloproliferative neoplasms (MPN) do not discriminate between arterial and venous …
CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …
Clonal hematopoiesis: from mechanisms to clinical intervention
T Köhnke, R Majeti - Cancer discovery, 2021 - AACR
Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …
Clonal hematopoiesis and its emerging effects on cellular therapies
The accumulation of somatic mutations in hematopoietic stem cells during aging, leading to
clonal expansion, is linked to a higher risk of cardiovascular mortality and hematologic …
clonal expansion, is linked to a higher risk of cardiovascular mortality and hematologic …
Discovering the drivers of clonal hematopoiesis
O Pich, I Reyes-Salazar, A Gonzalez-Perez… - Nature …, 2022 - nature.com
Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs)
drive clonal hematopoiesis (CH). While some CH drivers have been identified, the …
drive clonal hematopoiesis (CH). While some CH drivers have been identified, the …