The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson's disease: The way of new inroads

NH Ali, HM Al-Kuraishy, AI Al-Gareeb, SA Alnaaim… - Molecular …, 2024 - Springer
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …

Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine

S Wang, Q Han, Z Wei, Y Wang, J Xie… - Food and Chemical …, 2022 - Elsevier
Microplastics pollution has become a growing environmental concern, but its potential
neurotoxic effects remain unknown. In this study, we determined the effects of exposure to …

TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

J Yan, Y Zhang, L Wang, Z Li, S Tang, Y Wang… - Journal of …, 2022 - Springer
Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

Natural product-based pharmacological studies for neurological disorders

V Puri, N Kanojia, A Sharma, K Huanbutta… - Frontiers in …, 2022 - frontiersin.org
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

The role of BDNF as a biomarker in cognitive and sensory neurodegeneration

A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling

AM Gendy, A Soubh, MR Elnagar, E Hamza… - Food and Chemical …, 2023 - Elsevier
New insights into the role of berberine against 3-nitropropionic acid-induced striatal
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …

GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders

D Soni, P Kumar - Pharmacological Reports, 2022 - Springer
Movement disorders are neurological conditions characterized by involuntary motor
movements, such as dystonia, ataxia, chorea myoclonus, tremors, Huntington's disease …

Network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity

A Panossian, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …

7, 8-Dihydroxycoumarin alleviates synaptic loss by activated PI3K-Akt-CREB-BDNF signaling in Alzheimer's disease model mice

L Yan, Y Jin, J Pan, X He, S Zhong… - Journal of Agricultural …, 2022 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is clinically
characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in …