The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …
neuronal dysfunctionality which results in disability and human life-threatening events. In …
The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson's disease: The way of new inroads
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …
Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine
S Wang, Q Han, Z Wei, Y Wang, J Xie… - Food and Chemical …, 2022 - Elsevier
Microplastics pollution has become a growing environmental concern, but its potential
neurotoxic effects remain unknown. In this study, we determined the effects of exposure to …
neurotoxic effects remain unknown. In this study, we determined the effects of exposure to …
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice
J Yan, Y Zhang, L Wang, Z Li, S Tang, Y Wang… - Journal of …, 2022 - Springer
Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …
Natural product-based pharmacological studies for neurological disorders
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …
coming years, partly because of the world's aging population. Medicines for the treatment of …
The role of BDNF as a biomarker in cognitive and sensory neurodegeneration
A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …
system and in sensory structures including olfactory and auditory systems. Many studies …
New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling
New insights into the role of berberine against 3-nitropropionic acid-induced striatal
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …
GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders
Movement disorders are neurological conditions characterized by involuntary motor
movements, such as dystonia, ataxia, chorea myoclonus, tremors, Huntington's disease …
movements, such as dystonia, ataxia, chorea myoclonus, tremors, Huntington's disease …
Network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity
A Panossian, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …
7, 8-Dihydroxycoumarin alleviates synaptic loss by activated PI3K-Akt-CREB-BDNF signaling in Alzheimer's disease model mice
L Yan, Y Jin, J Pan, X He, S Zhong… - Journal of Agricultural …, 2022 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is clinically
characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in …
characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in …