Gene expression programmes conferring cellular identity are achieved through the
organization of chromatin structures that either facilitate or impede transcription. Among the …

Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

Wnt signaling usually functions through a spatial gradient. Localized Wnt3a signaling can
induce the asymmetric division of mouse embryonic stem cells, where proximal daughter …

Cortical neurogenesis depends on the balance between self‐renewal and differentiation of
apical progenitors (APs). Here, we study the epigenetic control of AP's division mode by …

During Drosophila melanogaster male germline stem cell (GSC) asymmetric division,
preexisting old versus newly synthesized histones H3 and H4 are asymmetrically inherited …

Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …

Nucleosome dynamics and properties are central to all forms of genomic activities. Among
the core histones, H3 variants play a pivotal role in modulating nucleosome structure and …

Asymmetric cell division produces two cells that are genetically identical but each have
distinctly different cell fates. During this process, epigenetic mechanisms play an important …

The discovery of biased histone inheritance in asymmetrically dividing Drosophila
melanogaster male germline stem cells demonstrates one means to produce two distinct …

Adult stem cells undergo asymmetric cell divisions to produce 2 daughter cells with distinct
cell fates: one capable of self-renewal and the other committed for differentiation …